1. The data to the right come from a microsatellite study of two ring seal
populations: one small population is isolated and landlocked in Lake
Saimaa. The “marine” population consists of all seals in the open ocean.
The alleles are named “195”, “191”, “189” … and so on. For example,
the frequency of allele “189” in Lake Saimaa is 0.156. This locus is
called “Hg8.10”, and it is in a region of DNA that does not code for
anything.
Calculate He for Lake Saimaa.

3. Pituitary dwarfism is a caused by a homozygous recessive condition at the growth hormone gene
GH1. The forward rate of mutation from the normal gene to the mutant form is 1 x 10-6. The
backward rate of mutation is so small that it can be ignored. If the frequency of the mutant allele is
now 0.1000, what will it be in 1000 generations? Assume no natural selection or drift.

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